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- Title
A Prospective Study of Plasma Selenium Levels and Prostate Cancer Risk.
- Authors
Haojie Li; Stampfer, Meir J.; Giovannucci, Edward L.; Morris, J. Steven; Willett, Walter C.; Gaziano, J. Michael; Jing Ma
- Abstract
Epidemiologic studies suggest that low selenium levels are associated with an increased incidence of prostate cancer, although results are conflicting. We examined the association between pre-diagnostic plasma selenium levels and risk of prostate cancer in men enrolled in the Physicians' Health Study. Pre-diagnostic plasma selenium levels were inversely associated with risk of advanced prostate cancer (5th versus 1stquintile OR = 0.52, 95% CI = 0.28 to 0.98; Ptrend = .05), even among men diagnosed after 1990 (5th versus 1st quintile OR = 0.39, 95% CI = 0.16 to 0.97). The inverse association with prostate cancer risk was observed only for case subjects with elevated baseline PSA levels (PSA >4 ng/mL, 5th versus 1st quintile OR = 0.49, 95% CI = 0.28 to 0.86; Ptrend = .002). These inverse associations were observed in both pre- and post-PSA eras. The inverse association between baseline plasma selenium levels and risk of advanced prostate cancer, even among men diagnosed during the post-PSA era, suggests that higher levels of selenium may slow prostate cancer tumor progression. Ongoing randomized trials of selenium supplements may help to further evaluate this issue.
- Publication
JNCI: Journal of the National Cancer Institute, 2004, Vol 96, Issue 9, p696
- ISSN
0027-8874
- Publication type
Academic Journal
- DOI
10.1093/jnci/djh125