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- Title
Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
- Authors
Stearns, Vered; Johnson, Michael D; Rae, James M; Morocho, Alan; Novielli, Antonella; Bhargava, Pankaj; Hayes, Daniel F; Desta, Zeruesenay; Flockhart, David A
- Abstract
Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-hydroxy-tamoxifen and other active metabolites by cytochrome P450 (CYP) enzymes. Selective serotonin reuptake inhibitors (SSRIs), which are often prescribed to alleviate tamoxifen-associated hot flashes, can inhibit CYPs. In a prospective clinical trial, we tested the effects of coadministration of tamoxifen and the SSRI paroxetine, an inhibitor of CYP2D6, on tamoxifen metabolism.
- Publication
Journal of the National Cancer Institute, 2003, Vol 95, Issue 23, p1758
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/djg108