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- Title
The epigenome as a target for cancer chemoprevention.
- Authors
Kopelovich, Levy; Crowell, James A; Fay, Judith R
- Abstract
Epigenetic events, a key driving force in the development of cancer, are alterations in gene expression without changes in the DNA coding sequence that are heritable through cell division. Such changes occur throughout all stages of tumorigenesis, including the early phases, and are increasingly recognized as major mechanisms involved in silencing tumor suppressor genes. Epigenetic changes can be reversed by the use of small molecules and, thus, such changes are promising targets for cancer chemopreventive drug development. This review examines the basis for targeting the epigenome as a prevention strategy, focusing on understanding the epigenetic changes that occur before the development of frank malignancy, when chemopreventive intervention will have the maximal impact.
- Publication
Journal of the National Cancer Institute, 2003, Vol 95, Issue 23, p1747
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/dig109