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- Title
p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.
- Authors
Sviderskaya, Elena V; Gray-Schopfer, Vanessa C; Hill, Simon P; Smit, Nico P; Evans-Whipp, Tracy J; Bond, Jane; Hill, Lucy; Bataille, Veronique; Peters, Gordon; Kipling, David; Wynford-Thomas, David; Bennett, Dorothy C
- Abstract
The melanoma susceptibility locus cyclin-dependent kinase inhibitor 2A encodes two unrelated cell growth inhibitors, p16 and alternative reading frame (ARF). In fibroblasts, both proteins are implicated in cellular senescence, a key barrier to tumor development. The p16 coding sequence is more often mutated in melanoma families than is the ARF sequence. To investigate the role of p16 in melanocytes, we assessed aspects of growth, apoptosis, and immortalization in melanocytes cultured from two melanoma patients, both of whom had two inactive p16 alleles but functional ARF.
- Publication
Journal of the National Cancer Institute, 2003, Vol 95, Issue 10, p723
- ISSN
1460-2105
- Publication type
Journal Article
- DOI
10.1093/jnci/95.10.723