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- Title
Host circadian clock as a control point in tumor progression.
- Authors
Filipski, Elisabeth; King, Verdun M; Li, XiaoMei; Granda, Teresa G; Mormont, Marie-Christine; Liu, XuHui; Claustrat, Bruno; Hastings, Michael H; Lévi, Francis
- Abstract
The circadian timing system controlled by the suprachiasmatic nuclei (SCN) of the hypothalamus regulates daily rhythms of motor activity and adrenocortical secretion. An alteration in these rhythms is associated with poor survival of patients with metastatic colorectal or breast cancer. We developed a mouse model to investigate the consequences of severe circadian dysfunction upon tumor growth.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 9, p690
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.9.690