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- Title
Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin.
- Authors
Nangia-Makker, Pratima; Hogan, Victor; Honjo, Yuichiro; Baccarini, Sara; Tait, Larry; Bresalier, Robert; Raz, Avraham
- Abstract
The role of dietary components in cancer progression and metastasis is an emerging field of clinical importance. Many stages of cancer progression involve carbohydrate-mediated recognition processes. We therefore studied the effects of high pH- and temperature-modified citrus pectin (MCP), a nondigestible, water-soluble polysaccharide fiber derived from citrus fruit that specifically inhibits the carbohydrate-binding protein galectin-3, on tumor growth and metastasis in vivo and on galectin-3-mediated functions in vitro.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 24, p1854
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.24.1854