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- Title
Effects of the herbal extract PC-SPES on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition.
- Authors
Bonham, Michael J; Galkin, Anna; Montgomery, Bruce; Stahl, William L; Agus, David; Nelson, Peter S
- Abstract
PC-SPES is a botanical preparation shown to have efficacy in patients with androgen-dependent and androgen-independent prostate carcinoma. Several herbal constituents in PC-SPES inhibit tumor growth through cell cycle arrest and apoptosis, although the mechanisms of these activities are poorly defined. We sought to identify PC-SPES-induced changes in gene expression, specifically in those genes encoding cytoskeletal proteins that could be associated with PC-SPES-induced cytoxicity.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 21, p1641
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.21.1641