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- Title
Herbal composition PC-SPES for management of prostate cancer: identification of active principles.
- Authors
Sovak, Milos; Seligson, Allen L; Konas, Martin; Hajduch, Marian; Dolezal, Marek; Machala, Miroslav; Nagourney, Robert
- Abstract
The herbal mixture PC-SPES, used to manage advanced prostate cancer, has proven thrombogenic and highly estrogenic in clinical trials. However, attempts to identify the active compounds in PC-SPES have yielded incongruous results. Moreover, warfarin was identified in the serum of a patient taking PC-SPES who experienced a bleeding disorder. To determine the active components in PC-SPES potentially responsible for these effects, we analyzed PC-SPES lots manufactured from l996 through mid-2001.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 17, p1275
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.17.1275