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- Title
Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.
- Authors
Mishima, Yuji; Matsumoto-Mishima, Yuko; Terui, Yasuhito; Katsuyama, Misa; Yamada, Muneo; Mori, Masaki; Ishizaka, Yukihito; Ikeda, Kazuma; Watanabe, Jun-ichiro; Mizunuma, Nobuyuki; Hayasawa, Hirotoshi; Hatake, Kiyohiko
- Abstract
Attachment of leukemic cells to vascular endothelial cells induces the vascular endothelial cells to release endothelial cell-derived interleukin 8 (endothelial IL-8), which then induces leukemic cells to undergo apoptosis. NB4, a human promyelocytic leukemic cell line that expresses high levels of cell-surface CD13/aminopeptidase N, does not undergo endothelial IL-8-induced apoptosis. Consequently, we investigated the relationship between cell-surface aminopeptidase activity and endothelial IL-8 induction of apoptosis in various leukemic cell lines.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 13, p1020
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.13.1020