We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer.
- Authors
Stoehlmacher, Jan; Park, David J; Zhang, Wu; Groshen, Susan; Tsao-Wei, Denice D; Yu, Mimi C; Lenz, Heinz-Josef
- Abstract
Members of the glutathione S-transferase (GST) superfamily are important in cellular defense mechanisms. These enzymes attach reduced glutathione to electrophilic groups in a wide variety of toxic compounds, including chemotherapeutic agents. Certain polymorphisms in GSTs are associated with changes in enzyme activity, sensitivity to chemotherapy, and overall patient survival. In a retrospective study, we investigated associations between common polymorphisms in genes for several GST subclasses (GSTP1, GSTT1, GSTM1) and survival of patients with metastatic colorectal cancer receiving 5-fluorouracil (5-FU)/oxaliplatin chemotherapy.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 12, p936
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.12.936