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- Title
Progestin-induced apoptosis in the Macaque ovarian epithelium: differential regulation of transforming growth factor-beta.
- Authors
Rodriguez, Gustavo C; Nagarsheth, Nimesh P; Lee, Karen L; Bentley, Rex C; Walmer, David K; Cline, Mark; Whitaker, Regina S; Isner, Pam; Berchuck, Andrew; Dodge, Richard K; Hughes, Claude L
- Abstract
Oral contraceptive (OC) use is associated with a reduced risk of ovarian cancer. An OC component, progestin, induces apoptosis in the primate ovarian epithelium. One regulator of apoptosis is transforming growth factor-beta (TGF-beta). We determined the effect of progestin on TGF-beta expression in the primate ovarian epithelium and examined the relationship between TGF-beta expression and apoptosis.
- Publication
Journal of the National Cancer Institute, 2002, Vol 94, Issue 1, p50
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/94.1.50