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- Title
Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome.
- Authors
Tripodis, N; Hart, A A; Fijneman, R J; Demant, P
- Abstract
Numerous low-penetrance genes control susceptibility to cancer in experimental animals, but the overall genetic information on this group of genes (i.e., number of loci and their mutual interactions) is missing. We performed a systematic search, scanning roughly half of the mouse genome for lung cancer susceptibility (Sluc) genes affecting tumor size or number by using mouse recombinant congenic (RC) strains. In each RC strain (OcB), approximately 12.5% of the genome is derived from the lung cancer-resistant strain B10.O20, whereas the rest is derived from the lung cancer-susceptible strain O20.
- Publication
Journal of the National Cancer Institute, 2001, Vol 93, Issue 19, p1484
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/93.19.1484