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- Title
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
- Authors
Long, D J, 2nd; Waikel, R L; Wang, X J; Roop, D R; Jaiswal, A K
- Abstract
The phase II enzyme NAD(P)H :quinone oxidoreductase 1 (NQO1) catalyzes quinone detoxification, protecting cells from redox cycling, oxidative stress, mutagenicity, and cytotoxicity induced by quinones and its precursors. We have used NQO1(-/-) C57BL/6 mice to show that NQO1 protects them from skin cancer induced by the polycyclic aromatic hydrocarbon benzo[a]pyrene. Herein, we used NQO1(-/-) mice to investigate whether NQO1 also protects them against 7,12-dimethylbenz[a]anthracene (DMBA), where methyl substituents diminish primary quinone formation.
- Publication
Journal of the National Cancer Institute, 2001, Vol 93, Issue 15, p1166
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/93.15.1166