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- Title
Patterns of her-2/neu amplification and overexpression in primary and metastatic breast cancer.
- Authors
Simon, R; Nocito, A; Hübscher, T; Bucher, C; Torhorst, J; Schraml, P; Bubendorf, L; Mihatsch, M M; Moch, H; Wilber, K; Schötzau, A; Kononen, J; Sauter, G
- Abstract
Only 25% of patients with HER-2/neu-positive metastatic breast tumors respond favorably to trastuzamab (Herceptin) treatment. We hypothesized that a high failure rate of patients on trastuzamab could result if some of the metastases were HER-2 negative and these metastases ultimately determine the course of the disease.
- Publication
Journal of the National Cancer Institute, 2001, Vol 93, Issue 15, p1141
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/93.15.1141