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- Title
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors.
- Authors
Esteller, M; Silva, J M; Dominguez, G; Bonilla, F; Matias-Guiu, X; Lerma, E; Bussaglia, E; Prat, J; Harkes, I C; Repasky, E A; Gabrielson, E; Schutte, M; Baylin, S B; Herman, J G
- Abstract
Inherited mutations in the BRCA1 gene may be responsible for almost half of inherited breast carcinomas. However, somatic (acquired) mutations in BRCA1 have not been reported, despite frequent loss of heterozygosity (LOH or loss of one copy of the gene) at the BRCA1 locus and loss of BRCA1 protein in tumors. To address whether BRCA1 may be inactivated by pathways other than mutations in sporadic tumors, we analyzed the role of hypermethylation of the gene's promoter region.
- Publication
Journal of the National Cancer Institute, 2000, Vol 92, Issue 7, p564
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/92.7.564