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- Title
Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma.
- Authors
Kawakami, K; Brabender, J; Lord, R V; Groshen, S; Greenwald, B D; Krasna, M J; Yin, J; Fleisher, A S; Abraham, J M; Beer, D G; Sidransky, D; Huss, H T; Demeester, T R; Eads, C; Laird, P W; Ilson, D H; Kelsen, D P; Harpole, D; Moore, M B; Danenberg, K D; Danenberg, P V; Meltzer, S J
- Abstract
The adenomatous polyposis coli (APC) locus on chromosome 5q21-22 shows frequent loss of heterozygosity (LOH) in esophageal carcinomas. However, the prevalence of truncating mutations in the APC gene in esophageal carcinomas is low. Because hypermethylation of promoter regions is known to affect several other tumor suppressor genes, we investigated whether the APC promoter region is hypermethylated in esophageal cancer patients and whether this abnormality could serve as a prognostic plasma biomarker.
- Publication
Journal of the National Cancer Institute, 2000, Vol 92, Issue 22, p1805
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/92.22.1805