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- Title
Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from The Gambia.
- Authors
Kirk, G D; Camus-Randon, A M; Mendy, M; Goedert, J J; Merle, P; Trépo, C; Bréchot, C; Hainaut, P; Montesano, R
- Abstract
A selective mutation, an arginine-to-serine substitution in codon 249, of the p53 gene has been identified as a "hotspot" mutation in hepatocellular carcinoma (HCC). This mutation occurs in populations that are exposed to aflatoxins and have a high prevalence of hepatitis B virus carriers. We evaluated whether this mutation could be detected in cell-free DNA isolated from the plasma of subjects from The Gambia to detect this mutation that is strongly associated with HCC.
- Publication
Journal of the National Cancer Institute, 2000, Vol 92, Issue 2, p148
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/92.2.148