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- Title
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
- Authors
Brinkman, A; van der Flier, S; Kok, E M; Dorssers, L C
- Abstract
Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors recur frequently because of the development of metastases that are resistant to tamoxifen. We have previously shown that mutagenesis of human estrogen-dependent ZR-75-1 breast cancer cells by insertion of a defective retrovirus genome caused the cells to become antiestrogen resistant. In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.
- Publication
Journal of the National Cancer Institute, 2000, Vol 92, Issue 2, p112
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/92.2.112