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- Title
Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
- Authors
Virmani, A K; Rathi, A; Zöchbauer-Müller, S; Sacchi, N; Fukuyama, Y; Bryant, D; Maitra, A; Heda, S; Fong, K M; Thunnissen, F; Minna, J D; Gazdar, A F
- Abstract
Retinoic acid plays an important role in lung development and differentiation, acting primarily via nuclear receptors encoded by the retinoic acid receptor-beta (RARbeta) gene. Because receptor isoforms RARbeta2 and RARbeta4 are repressed in human lung cancers, we investigated whether methylation of their promoter, P2, might lead to silencing of the RARbeta gene in human lung tumors and cell lines.
- Publication
Journal of the National Cancer Institute, 2000, Vol 92, Issue 16, p1303
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/92.16.1303