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- Title
Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.
- Authors
Shriver, S P; Bourdeau, H A; Gubish, C T; Tirpak, D L; Davis, A L; Luketich, J D; Siegfried, J M
- Abstract
Activation of gastrin-releasing peptide receptor (GRPR) in human airways has been associated with a proliferative response of bronchial cells to gastrin-releasing peptide and with long-term tobacco use. The GRPR gene is located on the X chromosome and escapes X-chromosome inactivation, which occurs in females. Increasing evidence demonstrates that women are more susceptible than men to tobacco carcinogenesis. We hypothesized that the susceptibility of women to the effects of tobacco may be associated with airway expression of GRPR.
- Publication
Journal of the National Cancer Institute, 2000, Vol 92, Issue 1, p24
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/92.1.24