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- Title
Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations.
- Authors
Phillips, K A; Nichol, K; Ozcelik, H; Knight, J; Done, S J; Goodwin, P J; Andrulis, I L
- Abstract
Breast carcinomas occurring in carriers of BRCA1 gene mutations may have a distinctly different pathway of molecular pathogenesis from those occurring in noncarriers. Data from murine models implicate loss of p53 (also known as TP53) gene function as a critical early event in the malignant transformation of cells with a BRCA1 mutation. Therefore, breast tumors from BRCA1 mutation carriers might be expected to exhibit a high frequency of p53 mutations. This study examined the frequency of p53 mutations in the breast tumors of Ashkenazi Jewish carriers and noncarriers of BRCA1 mutations.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 5, p469
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.5.469