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- Title
Association between nonrandom X-chromosome inactivation and BRCA1 mutation in germline DNA of patients with ovarian cancer.
- Authors
Buller, R E; Sood, A K; Lallas, T; Buekers, T; Skilling, J S
- Abstract
Most human female cells contain two X chromosomes, only one of which is active. The process of X-chromosome inactivation, which occurs early in development, is usually random, producing tissues with equal mixtures of cells having active X chromosomes of either maternal or paternal origin. However, nonrandom inactivation may occur in a subset of females. If a tumor suppressor gene were located on the X chromosome and if females with a germline mutation in one copy of that suppressor gene experienced nonrandom X-chromosome inactivation, then some or all of the tissues of such women might lack the wild-type suppressor gene function. This scenario could represent a previously unrecognized mechanism for development of hereditary cancers. We investigated whether such a mechanism might contribute to the development of hereditary ovarian cancers.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 4, p339
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.4.339