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- Title
Clonal expansion and loss of heterozygosity at chromosomes 9p and 17p in premalignant esophageal (Barrett's) tissue.
- Authors
Galipeau, P C; Prevo, L J; Sanchez, C A; Longton, G M; Reid, B J
- Abstract
Abnormalities involving the p16 (also known as cyclin-dependent kinase N2 [CDKN2], p16 [INK4a], or MTS1) and p53 (also known as TP53) tumor suppressor genes are highly prevalent in esophageal adenocarcinomas. Loss of heterozygosity (LOH) at 9p21 and 17p13 chromosomes (locations for p16 and p53 genes, respectively) is frequently observed in the premalignant condition, Barrett's esophagus. We studied extensively the distribution and heterogeneity of LOH at 9p and 17p chromosomes throughout the Barrett's segment in patients who have not yet developed esophageal adenocarcinoma.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 24, p2087
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.24.2087