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- Title
Gemcitabine transport in xenopus oocytes expressing recombinant plasma membrane mammalian nucleoside transporters.
- Authors
Mackey, J R; Yao, S Y; Smith, K M; Karpinski, E; Baldwin, S A; Cass, C E; Young, J D
- Abstract
Gemcitabine, a pyrimidine analogue of deoxycytidine, is an anticancer nucleoside drug that requires functional plasma membrane nucleoside transporter proteins to reach its intracellular targets and cause cytotoxicity. Because of technical difficulties inherent in studying nucleoside transport in human cells, we rigorously defined gemcitabine membrane transportability by producing each of the available human (h) and rat (r) recombinant nucleoside transporters (NTs) individually in Xenopus laevis oocytes.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 21, p1876
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.21.1876