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- Title
Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers.
- Authors
Rebbeck, T R; Levin, A M; Eisen, A; Snyder, C; Watson, P; Cannon-Albright, L; Isaacs, C; Olopade, O; Garber, J E; Godwin, A K; Daly, M B; Narod, S A; Neuhausen, S L; Lynch, H T; Weber, B L
- Abstract
The availability of genetic testing for inherited mutations in the BRCA1 gene provides potentially valuable information to women at high risk of breast or ovarian cancer; however, carriers of BRCA1 mutations have few clinical management options to reduce their cancer risk. Decreases in ovarian hormone exposure following bilateral prophylactic oophorectomy (i.e., surgical removal of the ovaries) may alter cancer risk in BRCA1 mutation carriers. This study was undertaken to evaluate whether bilateral prophylactic oophorectomy is associated with a reduction in breast cancer risk in BRCA1 mutation carriers.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 17, p1475
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.17.1475