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- Title
Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer.
- Authors
Warner, E; Foulkes, W; Goodwin, P; Meschino, W; Blondal, J; Paterson, C; Ozcelik, H; Goss, P; Allingham-Hawkins, D; Hamel, N; Di Prospero, L; Contiga, V; Serruya, C; Klein, M; Moslehi, R; Honeyford, J; Liede, A; Glendon, G; Brunet, J S; Narod, S
- Abstract
Approximately 2.0%-2.5% of Ashkenazi Jewish women carry one of three founding mutations in the BRCA1 and BRCA2 genes, and each mutation is associated with a high lifetime risk of invasive breast cancer. We investigated the extent to which these three mutations contribute to breast cancer incidence in the Ashkenazi Jewish population.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 14, p1241
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.14.1241