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- Title
Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke.
- Authors
Wang, X D; Liu, C; Bronson, R T; Smith, D E; Krinsky, N I; Russell, M
- Abstract
Epidemiologic studies have demonstrated that individuals who eat more fruits and vegetables and/or have high levels of serum beta-carotene have a lower risk of cancer, especially lung cancer. However, recent human intervention studies using beta-carotene supplements have shown an increase in the risk of lung cancer among smokers and asbestos workers. In this study, we used an animal model system to evaluate the hazard associated with a combination of high-dose beta-carotene supplementation and tobacco smoking.
- Publication
Journal of the National Cancer Institute, 1999, Vol 91, Issue 1, p60
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/91.1.60