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- Title
Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients.
- Authors
Spitz, M R; Shi, H; Yang, F; Hudmon, K S; Jiang, H; Chamberlain, R M; Amos, C I; Wan, Y; Cinciripini, P; Hong, W K; Wu, X
- Abstract
Interindividual differences in the structure and expression of the dopamine receptor genes affect dopamine availability and may be the genetic basis for variation in vulnerability to tobacco smoking. In this study, prevalences of polymorphisms in the TaqIA allele (A1 and A2) and the TaqIB allele (B1 and B2) of the D2 dopamine receptor gene in 157 lung cancer case patients and 126 control subjects were determined to assess whether individuals homozygous or heterozygous for the less common A1 and B1 alleles are more vulnerable to nicotine addiction.
- Publication
Journal of the National Cancer Institute, 1998, Vol 90, Issue 5, p358
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/90.5.358