We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.
- Authors
Warrell, R P, Jr; He, L Z; Richon, V; Calleja, E; Pandolfi, P P
- Abstract
Acetylation of DNA-associated histones is linked to activation of gene transcription, whereas histone deacetylation is associated with transcriptional repression. Recent studies have shown that inhibitors of histone deacetylases can relieve transcriptional repression caused by the products of certain oncogenes. We tested whether these findings could be applied clinically to a patient with highly resistant acute promyelocytic leukemia.
- Publication
Journal of the National Cancer Institute, 1998, Vol 90, Issue 21, p1621
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/90.21.1621