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- Title
Rates of Jewish ancestral mutations in BRCA1 and BRCA2 in borderline ovarian tumors.
- Authors
Gotlieb, W H; Friedman, E; Bar-Sade, R B; Kruglikova, A; Hirsh-Yechezkel, G; Modan, B; Inbar, M; Davidson, B; Kopolovic, J; Novikov, I; Ben-Baruch, G
- Abstract
Germline mutations in the BRCA1 and BRCA2 genes are known to be associated with an increased risk of breast and epithelial ovarian cancers. Two specific mutations, 185delAG-BRCA1 and 6174delT-BRCA2, have been detected in a substantial proportion (20%-60%) of unselected Ashkenazi Jewish patients--i.e., Jewish patients of Eastern/Northern European descent--with invasive ovarian cancer and in a measurable proportion (2%) of the general Ashkenazi Jewish population. However, uncertainty exists concerning the heritable basis of borderline ovarian tumors and whether these tumors represent an early form of ultimately invasive disease. To gain insight into these issues, we determined the rates of 185delAG-BRCA1 and 6174delT-BRCA2 mutations in patients with borderline ovarian tumors.
- Publication
Journal of the National Cancer Institute, 1998, Vol 90, Issue 13, p995
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/90.13.995