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- Title
Hereditary pancreatitis and the risk of pancreatic cancer. International Hereditary Pancreatitis Study Group.
- Authors
Lowenfels, A B; Maisonneuve, P; DiMagno, E P; Elitsur, Y; Gates, L K, Jr; Perrault, J; Whitcomb, D C
- Abstract
Hereditary pancreatitis is an autosomal-dominant disease, with a variable expression and an estimated penetrance of 80%. The gene for this disease has recently been mapped to chromosome 7q35, and the defect is believed to be caused by a mutation in the cationic trypsinogen gene. Acute attacks of abdominal pain begin early in life and the disease often progresses to chronic pancreatitis. Although the risk of pancreatic cancer is thought to be increased in more common types of chronic pancreatitis, the frequency of pancreatic cancer in the inherited type of pancreatitis is uncertain.
- Publication
Journal of the National Cancer Institute, 1997, Vol 89, Issue 6, p442
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/89.6.442