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Title
Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history.
Authors
Berry, D A; Parmigiani, G; Sanchez, J; Schildkraut, J; Winer, E
Abstract
Heritable mutations of the breast cancer gene BRCA1 are rare, occurring in fewer than 1% of women in the general population, and therefore account for a small proportion of cases of breast and ovarian cancers. Nevertheless, the presence of such mutations is highly predictive of the development of these cancers.
Publication
Journal of the National Cancer Institute, 1997, Vol 89, Issue 3, p227