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- Title
Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer.
- Authors
Zahnow, C A; Younes, P; Laucirica, R; Rosen, J M
- Abstract
When cells fail to maintain a balance between proliferation, terminal differentiation, and programmed cell death, cancer often results. The CCAAT/enhancer-binding protein (C/EBP) family of transcription factors regulates many genes involved in the processes of proliferation and terminal differentiation. The messenger RNA for C/EBPbeta is translated into two major isoforms, LAP (liver-enriched activating protein) and LIP (liver-enriched inhibitory protein). LIP levels appear to be elevated in mouse mammary tumors but not in hyperplastic mammary tissues. We tested whether LIP expression is elevated in human breast cancer and whether elevated expression is associated with biologic predictors of the aggressiveness of the disease.
- Publication
Journal of the National Cancer Institute, 1997, Vol 89, Issue 24, p1887
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/89.24.1887