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- Title
Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers.
- Authors
Harty, L C; Caporaso, N E; Hayes, R B; Winn, D M; Bravo-Otero, E; Blot, W J; Kleinman, D V; Brown, L M; Armenian, H K; Fraumeni, J F, Jr; Shields, P G
- Abstract
The consumption of alcoholic beverages is a strong risk factor for cancers of the oral cavity and pharynx (oral cancers). Alcohol dehydrogenase type 3 (ADH3) metabolizes ethanol to acetaldehyde, a carcinogen. We evaluated whether individuals homozygous for the fast-metabolizing ADH3(1) allele (ADH3[1-1]) have a greater risk of developing oral cancer in the presence of alcoholic beverage consumption than those with the slow-metabolizing ADH3(2) allele (ADH3[1-2] and ADH3[2-2]).
- Publication
Journal of the National Cancer Institute, 1997, Vol 89, Issue 22, p1698
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/89.22.1698