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- Title
Enhancing efficacy of recombinant anticancer vaccines with prime/boost regimens that use two different vectors.
- Authors
Irvine, K R; Chamberlain, R S; Shulman, E P; Surman, D R; Rosenberg, S A; Restifo, N P
- Abstract
The identification of tumor-associated antigens and the cloning of DNA sequences encoding them have enabled the development of anticancer vaccines. Such vaccines target tumors by stimulating an immune response against the antigens. One method of vaccination involves the delivery of antigen-encoding DNA sequences, and a number of recombinant vectors have been used for this purpose. To optimize the efficacy of recombinant vaccines, we compared primary and booster treatment regimens that used a single vector (i.e., homologous boosting) with regimens that used two different vectors (i.e., heterologous boosting).
- Publication
Journal of the National Cancer Institute, 1997, Vol 89, Issue 21, p1595
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/89.21.1595