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- Title
Nurses' health study: log-incidence mathematical model of breast cancer incidence.
- Authors
Rosner, B; Colditz, G A
- Abstract
In 1983, Pike et al. developed a mathematical model to quantify the effects of reproductive risk factors on the incidence of breast cancer. In 1994, we modified that model to correct some deficiencies in the original model, including a lack of terms for spacing of births and an inability to easily accommodate births after age 40 years. Our extended Pike model, while improving on the original, still has serious disadvantages, such as difficulty in translating model parameters into relative risks (RRs) and an incomplete fit to data that slightly overestimated incidence for premenopausal women with an early age at first birth and that underestimated incidence for post-menopausal women with a late age at first birth.
- Publication
Journal of the National Cancer Institute, 1996, Vol 88, Issue 6, p359
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/88.6.359