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- Title
Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance.
- Authors
Albanes, D; Heinonen, O P; Taylor, P R; Virtamo, J; Edwards, B K; Rautalahti, M; Hartman, A M; Palmgren, J; Freedman, L S; Haapakoski, J; Barrett, M J; Pietinen, P; Malila, N; Tala, E; Liippo, K; Salomaa, E R; Tangrea, J A; Teppo, L; Askin, F B; Taskinen, E; Erozan, Y; Greenwald, P; Huttunen, J K
- Abstract
Experimental and epidemiologic investigations suggest that alpha-tocopherol (the most prevalent chemical form of vitamin E found in vegetable oils, seeds, grains, nuts, and other foods) and beta-carotene (a plant pigment and major precursor of vitamin A found in many yellow, orange, and dark-green, leafy vegetables and some fruit) might reduce the risk of cancer, particularly lung cancer. The initial findings of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC Study) indicated, however, that lung cancer incidence was increased among participants who received beta-carotene as a supplement. Similar results were recently reported by the Beta-Carotene and Retinol Efficacy Trial (CARET), which tested a combination of beta-carotene and vitamin A.
- Publication
Journal of the National Cancer Institute, 1996, Vol 88, Issue 21, p1560
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/88.21.1560