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- Title
Development of retinoblastoma in the absence of telomerase activity.
- Authors
Gupta, J; Han, L P; Wang, P; Gallie, B L; Bacchetti, S
- Abstract
The length and stability of telomeres (essential functional structures at the end of eukaryotic chromosomes) have been implicated in the control of cell lifespan. Most somatic cells lack telomerase, the enzyme that synthesizes telomeric DNA, and their telomeres shorten with cell division. Cells immortalized in vitro, on the other hand, express telomerase and maintain their telomeres. Telomerase activity has also been detected in the large majority of tumors from a variety of cancers. These observations have suggested that telomere maintenance is required for unlimited cell proliferation and that telomerase is a marker for cell immortality in vitro and in vivo.
- Publication
Journal of the National Cancer Institute, 1996, Vol 88, Issue 16, p1152
- ISSN
0027-8874
- Publication type
Journal Article
- DOI
10.1093/jnci/88.16.1152