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- Title
DNA methylation and atherosclerosis.
- Authors
Dong, Chunming; Yoon, Woohyun; Goldschmidt-Clermont, Pascal J
- Abstract
DNA methylation is a major epigenetic modification of the genome that has the potential to silence gene expression. Recently, the role of epigenetic alteration as a distinct and crucial mechanism to regulate genes governing cell proliferation in atherosclerosis has emerged. Aberrant methylation is related to aging, and, because it affects a large number of CpG islands, age-related methylation may be an important contributor to increased atherosclerosis among older individuals by upregulating atherosclerosis-susceptible genes and downregulating atherosclerosis-protective genes. Further dissection of epigenetic alterations in atherosclerosis and aging will lead to the identification of novel epigenetic modifiers and improved diagnosis and treatment for atherosclerosis-related diseases.
- Publication
The Journal of nutrition, 2002, Vol 132, Issue 8 Suppl, p2406S
- ISSN
0022-3166
- Publication type
Journal Article
- DOI
10.1093/jn/132.8.2406S