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- Title
Effects of a prolonged vitamin E deficiency in the rat.
- Authors
Machlin, L J; Filipski, R; Nelson, J; Horn, L R; Brin, M
- Abstract
Rats fed a vitamin E-deficient diet containing 10% "stripped" corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected the E-deficient rats.
- Publication
The Journal of nutrition, 1977, Vol 107, Issue 7, p1200
- ISSN
0022-3166
- Publication type
Journal Article
- DOI
10.1093/jn/107.7.1200