We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Applications of post-translational modifications of FoxO family proteins in biological functions.
- Authors
Zhao, Ying; Wang, Yachen; Zhu, Wei-Guo
- Abstract
The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.
- Publication
Journal of molecular cell biology, 2011, Vol 3, Issue 5, p276
- ISSN
1759-4685
- Publication type
Journal Article
- DOI
10.1093/jmcb/mjr013