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Title
Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.
Authors
Liu, Chunming; He, Xi
Abstract
A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/beta-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a beta-catenin destructor.