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- Title
A feasibility study of induction pemetrexed plus cisplatin followed by pleurectomy/decortication aimed at macroscopic complete resection for malignant pleural mesothelioma.
- Authors
Shimokawa, Mototsugu; Hasegawa, Seiki; Fukuoka, Kazuya; Okada, Morihito; Yokoi, Kohei; Tanaka, Fumihiro; Yamanaka, Takeharu; Daimon, Takashi; Nakano, Takashi
- Abstract
A prospective multi-institutional study has been initiated in Japan to evaluate the feasibility of induction chemotherapy using pemetrexed plus cisplatin, followed by pleurectomy/decortication aimed at macroscopic complete resection in patients with resectable malignant pleural mesothelioma. The study was initiated on September 2012, for which 24 patients will be recruited over a period of 2 years. The primary endpoint is the macroscopic complete resection rate, regardless of the surgical technique employed (i.e. pleurectomy/decortication or extrapleural pneumonectomy). The secondary endpoints are the pleurectomy/decortication rate, macroscopic complete resection rate by pleurectomy/decortication, pulmonary function at 3 months after surgery, adverse events, treatment-related mortality, response rate to chemotherapy and 3-year overall survival rate.
- Publication
Japanese journal of clinical oncology, 2013, Vol 43, Issue 5, p575
- ISSN
1465-3621
- Publication type
Journal Article
- DOI
10.1093/jjco/hyt035