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- Title
Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats.
- Authors
Kehler, James S; David, Victor A; Schäffer, Alejandro A; Bajema, Kristina; Eizirik, Eduardo; Ryugo, David K; Hannah, Steven S; O'Brien, Stephen J; Menotti-Raymond, Marilyn
- Abstract
To determine the genetic regulation of "hair length" in the domestic cat, a whole-genome scan was performed in a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds > or = 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candidate gene implicated in regulating hair follicle growth cycle in other species. Sequence analyses of FGF5 in 26 cat breeds and 2 pedigrees of nonbreed cats revealed 4 separate mutations predicted to disrupt the biological activity of the FGF5 protein. Pedigree analyses demonstrated that different combinations of paired mutant FGF5 alleles segregated with the long-haired phenotype in an autosomal recessive manner. Association analyses of more than 380 genotyped breed and nonbreed cats were consistent with mutations in the FGF5 gene causing the long-haired phenotype in an autosomal recessive manner. In combination, these genomic approaches demonstrated that FGF5 is the major genetic determinant of hair length in the domestic cat.
- Publication
The Journal of heredity, 2007, Vol 98, Issue 6, p555
- ISSN
0022-1503
- Publication type
Journal Article
- DOI
10.1093/jhered/esm072