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- Title
An efficient RNA aptamer against human influenza B virus hemagglutinin.
- Authors
Gopinath, Subash C B; Sakamaki, Yuriko; Kawasaki, Kazunori; Kumar, Penmetcha K R
- Abstract
Aptamers are known for their higher discriminating ability between closely related molecules and their requirement for only a small region for binding, as compared to an antibody. In the present studies, we have isolated a specific RNA aptamer against the influenza virus B/Johannesburg/05/1999 by an in vitro selection procedure. The aptamer bound efficiently to the HA of influenza B and required 5 mM MgCl(2) ion for its recognition. The aptamer not only distinguished HA derived from the influenza A virus, but also inhibited HA-mediated membrane fusion.
- Publication
Journal of biochemistry, 2006, Vol 139, Issue 5, p837
- ISSN
0021-924X
- Publication type
Journal Article
- DOI
10.1093/jb/mvj095