We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Physiological roles of SAPK/JNK signaling pathway.
- Authors
Nishina, Hiroshi; Wada, Teiji; Katada, Toshiaki
- Abstract
Stress-activated protein kinase/c-Jun NH(2)-terminal kinase (SAPK/JNK) is activated by many types of cellular stresses and extracellular signals. Recent studies, including the analysis with knockout mice, have led to progress towards understanding the physiological roles of SAPK/JNK activation in embryonic development in addition to immune responses. SAPK/JNK activation plays essential roles in organogenesis during mouse development by regulating cell survival, apoptosis, and proliferation. Two SAPK/JNK activators, SEK1 and MKK7, are required for fetal liver formation and full activation of SAPK/JNK, which responds to various stimuli in an all-or-none manner. This article focuses on physiological roles of SAPK/JNK activation in fetal liver formation and in apoptosis regulation.
- Publication
Journal of biochemistry, 2004, Vol 136, Issue 2, p123
- ISSN
0021-924X
- Publication type
Journal Article
- DOI
10.1093/jb/mvh117