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- Title
Cranberry-derived proanthocyanidins prevent formation of Candida albicans biofilms in artificial urine through biofilm- and adherence-specific mechanisms.
- Authors
Rane, Hallie S; Bernardo, Stella M; Howell, Amy B; Lee, Samuel A
- Abstract
Candida albicans is a common cause of nosocomial urinary tract infections (UTIs) and is responsible for increased morbidity and healthcare costs. Moreover, the US Centers for Medicare & Medicaid Services no longer reimburse for hospital-acquired catheter-associated UTIs. Thus, development of specific approaches for the prevention of Candida urinary infections is needed. Cranberry juice-derived proanthocyanidins (PACs) have efficacy in the prevention of bacterial UTIs, partially due to anti-adherence properties, but there are limited data on their use for the prevention and/or treatment of Candida UTIs. Therefore, we sought to systematically assess the in vitro effect of cranberry-derived PACs on C. albicans biofilm formation in artificial urine.
- Publication
The Journal of antimicrobial chemotherapy, 2014, Vol 69, Issue 2, p428
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkt398