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- Title
Fitness cost: a bacteriological explanation for the demise of the first international methicillin-resistant Staphylococcus aureus epidemic.
- Authors
Nielsen, Karen L; Pedersen, Thomas M; Udekwu, Klas I; Petersen, Andreas; Skov, Robert L; Hansen, Lars H; Hughes, Diarmaid; Frimodt-Møller, Niels
- Abstract
Denmark and several other countries experienced the first epidemic of methicillin-resistant Staphylococcus aureus (MRSA) during the period 1965-75, which was caused by multiresistant isolates of phage complex 83A. In Denmark these MRSA isolates disappeared almost completely, being replaced by other phage types, predominantly only penicillin resistant. We investigated whether isolates of this epidemic were associated with a fitness cost, and we employed a mathematical model to ask whether these fitness costs could have led to the observed reduction in frequency.
- Publication
The Journal of antimicrobial chemotherapy, 2012, Vol 67, Issue 6, p1325
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dks051