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- Title
Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection.
- Authors
Alcalá-Franco, Beatriz; Montanari, Sara; Cigana, Cristina; Bertoni, Giovanni; Oliver, Antonio; Bragonzi, Alessandra
- Abstract
Hypermutable strains of Pseudomonas aeruginosa frequently emerge during chronic airways infection in cystic fibrosis (CF) patients. While the increased accumulation of mutations by hypermutable strains determines a biological cost for the colonization of secondary environments, the mutator phenotypes might confer a selective advantage under antibiotic treatment in a CF airways environment.
- Publication
The Journal of antimicrobial chemotherapy, 2012, Vol 67, Issue 4, p962
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkr587