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- Title
Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
- Authors
Xing, Sifei; Bhat, Shridhar; Shroff, Neeta S; Zhang, Hao; Lopez, Joseph A; Margolick, Joseph B; Liu, Jun O; Siliciano, Robert F
- Abstract
The latent reservoir of HIV-1 in resting memory CD4+ T cells is a major barrier to curing HIV-1 infection. Eradication strategies involve reactivation of this latent reservoir; however, agents that reactivate latent HIV-1 through non-specific T cell activation are toxic.
- Publication
The Journal of antimicrobial chemotherapy, 2012, Vol 67, Issue 2, p398
- ISSN
1460-2091
- Publication type
Journal Article
- DOI
10.1093/jac/dkr496